Hydrodynamics and bioprocess considerations in designing bioreactors for cardiac tissue engineering

Hydrodynamics and bioprocess considerations in designing bioreactors for cardiac tissue engineering

One of the most attractive fields in regenerative medicine and tissue engineering is cardiac cell regeneration due to the limited capacity of the heart muscle to regenerate itself. Recent advances in the field of stem cell bioprocess technology and biomaterials have accelerated progress in creating three-dimensional (3D) cardiac engineered tissues in vitro. Control of bulk and microscopic trans...

Bioreactors in tissue engineering.

A bioreactor can be defined as a device that uses mechanical means to influence biological processes. In tissue engineering bioreactors can be used to aid in the in vitro development of new tissue by providing biochemical and physical regulatory signals to cells and encouraging them to undergo differentiation and/or to produce extracellular matrix prior to in vivo implantation. This chapter dis...

Bioreactors for Liver Tissue Engineering

A cute liver failure (ALF) patients have a high risk of mortality. The elective treatment for ALF still is orthotopic liver transplantation. Donor organ scarcity and the associated high costs make transplantation possible for only about one third of the patients on the transplantation waiting list. Engineering a biological liver substitute is an interesting alternative to the traditional ALF th...

IV.3. Bioreactors in tissue engineering.

Manufacturing a Biomimetic Biorecator in Cardiac Tissue Engineering

Introduction: The direct approach of cardiac tissue engineering is to mimic the natural tissue of heart, considering the significant role of scaffolding and mechanical simulation.  Methods: To achieve this purpose, a composite Polycaprolactone (PCL)/Gelatin electrospun scaffold with a ratio of 70:30 and with the most similarities to the cardiac extracellular matrix was fabricated with aligned ...